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In both ileal and cecal content, members of the Lachnospiraceae Family significantly contributed to the changes observed. Alterations in the microbial community structure and bile acid pool were seen in ileal and cecal content compared to pretreatment, and longitudinally in feces following the 21-day ursodiol treatment. Significant weight loss was seen in mice treated with the low and high dose of ursodiol. Alterations in the gut microbiota and bile acids were examined including stool, ileal, and cecal content. C57BL/6J wildtype mice were given one of three doses of ursodiol (50, 150, or 450 mg/kg/day) by oral gavage for 21 days.
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This study aims to characterize how ursodiol alters the gastrointestinal ecosystem in conventional mice. Despite these interactions, it remains unclear if and how exogenously administered ursodiol shapes the gut microbial community structure and bile acid pool in conventional mice. In turn, the gut microbial community can modulate bile acid pools, thus highlighting the interconnectedness of the gut microbiota-bile acid-host axis. Ursodiol can modulate bile acid pools, which have the potential to alter the gut microbiota community structure.
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Moreover, this release comes with some major bug fixations. Some improvements are also involved regarding their performance and speed. Also, this version comes with the modified appearance of its icon. It includes the ability to change the color or type of point for individual data points. With these options, mean values for some multiple comparisons were calculated incorrectly only affected version 8. Moreover, it helps you to calculate the area under the curve.Īlso, this software helps you to get the Receiver operator characteristic ROC curves. This application allows you to collaborate with other scientists. It helps you to perform graphing programs and spreadsheets.
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